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笔厂顿95结合蛋白3抗体
产物名称 | 英文名称 | 货号 |
PSD95结合蛋白3抗体 | SAPAP3 | GOY-01K1106 |
商品属性：
英文名称: SAPAP3
中文名:PSD95结合蛋白3抗体
别 名；PSD95BP3; DLGAP3;
PSD 95/SAP90 binding protein 3; SAP90/PSD 95 associated protein 3; DAP3; Discs,
large (Drosophila) homolog associated protein 3; Disks large associated protein
3; DLGAP3; SAPAP 3; DLGP3_HUMAN.
研究领域；神经生物学 信号转导 细胞类型标志物 细胞膜蛋白
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Dog, Cow, Horse, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；106kDa
细胞定位；细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human SAPAP3: 201-300/979
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Members of the postsynaptic density-95
(PSD-95)/SAP90 family of membrane-associated guanylate kinase (MAGUK)
proteins function as multimodular scaffolds that organize protein-signaling
complexes at neuronal synapses. SAPAP3 (PSD-95/SAP90-binding protein 3), also
known as DLGAP3 (disks large-associated protein 3) or DAP3, is a 979 amino
acid protein that belongs to the SAPAP family of PSD-95/SAP90-associated proteins.
Localized to the cell junction, as well as to the peripheral membrane and the
cell synapse, SAPAP3 is thought to play a role in the organization of
neuronal cell signaling and synapses, and may also function as an adaptor
protein, possibly linking ion channels with the cytoskeleton. SAPAP3, (DLGAP3) is a member of a protein family
whose members specifically interact with PSD-95/SAP90, a membrane-associated
guanylate kinase localized at postsynaptic density (PSD) in neuronal cells.
Like the other SAPAP proteins, SAPAP3 is thought to be an adaptor protein
that also interacts with different synaptic scaffolding proteins,
cytoskeletal and signaling components, such as focal adhesion kinase (FAK)
and proline-rich tyrosine kinase 2 (PYK2). Both SAPAP3 protein and mRNA are
targeted to dendrites, whereas SAPAP1, -2, and -4 mRNAs are detected mainly
in cell bodies. Recent experiments have suggested that SAPAP3 may be involved
in obsessive-compulsive disorder (OCD), as mice lacking SAPAP3 exhibited
OCD-like symptoms which could be relieved by lentiviral-mediated selective
expression of SAPAP3 in the striatum of SAPAP3-mutant mice. At least two
isoforms are known to exist. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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